Help Ease Flu-Related Symptoms with Tamiflu
Treatment with Tamiflu significantly reduces the duration of influenza.1
TAMIFLU is indicated for the treatment of acute, uncomplicated illness due to influenza infection in patients 2 weeks of age and older who have been symptomatic for no more than 2 days.
Tamiflu significantly reduced flu duration by 32 hours versus placebo (P<0.001).1,14
About the study
Results are from a randomized, placebo-controlled, double-blind study conducted January through March 1998. The study population included 629 healthy, nonimmunized adults aged 18 to 65 years. In the experimental arm, Tamiflu was administered within 2 days of symptom onset at a twice-daily dose of 75 mg for 5 days. The primary efficacy end point was time to improvement, which was calculated from the time of treatment initiation to the time when all symptoms (nasal congestion, sore throat, cough, aches, fatigue, headaches, and chills/sweats) were assessed as “none” or “mild.”
Limitations of Use
The following points should be considered before initiating treatment with Tamiflu:
- Efficacy of Tamiflu in patients who begin treatment after 48 hours of symptoms has not been established.1
- Tamiflu is not a substitute for early influenza vaccination on an annual basis as recommended by the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices.12, 13, 18, 27
- There is no evidence for efficacy of Tamiflu in any illness caused by agents other than influenza virus Types A and B.1
- Influenza viruses change over time. Emergence of resistant mutations could decrease drug effectiveness. Other factors (for example, changes in viral virulence) might also diminish clinical benefit of antiviral drugs. Prescribers should consider available information on influenza drug susceptibility patterns and treatment effects when deciding whether to use Tamiflu.13
Tamiflu is contraindicated in patients with known serious hypersensitivity to oseltamivir or any component of the product. Severe allergic reactions have included anaphylaxis and serious skin reactions, such as toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme, to any component of Tamiflu.1
Please see the Tamiflu full Prescribing Information for complete safety information.
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Use the Tamiflu dosing reference.
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*Adapted from the Tamiflu full Prescription information.