How to Treat Influenza in Children Aged 1-12 Years
Tamiflu significantly reduced flu duration by 36 hours (26%) compared with placebo in children aged 1 through 12 years.8
Tamiflu is indicated for the treatment of acute, uncomplicated illness due to influenza infection in patients 2 weeks of age and older who have been symptomatic for no more than 2 days.
About the study
- Tamiflu significantly reduced flu duration by 26% (36 hours) vs placebo (P<0.0001).8
- Tamiflu reduced median duration of fever by 25 hours.8
Results are from a double-blind, placebo-controlled treatment trial conducted in 698 pediatric subjects aged 1 to 12 years. All included patients had fever (≥100°F) plus 1 respiratory symptom (cough or coryza), and 452 were influenza-infected. Study participants received Tamiflu 2 mg/kg twice daily or placebo within 2 days of symptom onset. The primary efficacy end point was time to freedom from illness, a composite end point that required 4 individual conditions be met: alleviation of cough, alleviation of coryza, resolution of fever, and parental opinion of a return to normal health and activity.
Limitations of Use
The following points should be considered before initiating treatment with Tamiflu:
- Efficacy of Tamiflu in patients who begin treatment after 48 hours of symptoms has not been established.1
- Tamiflu is not a substitute for early and annual influenza vaccination as recommended by the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices.1
- There is no evidence for efficacy of Tamiflu in any illness caused by agents other than influenza virus types A and B.1
- Influenza viruses change over time. Emergence of resistance mutations could decrease drug effectiveness. Other factors (for example, changes in viral virulence) might also diminish clinical benefit of antiviral drugs. Prescribers should consider available information on influenza drug susceptibility patterns and treatment effects when deciding whether to use Tamiflu.1
Please see the Tamiflu full Prescribing Information for complete safety information.
Next Step: Learn about prescribing Tamiflu for prophylaxis in pediatric patients ›
Did you know?
In a clinical study, Tamiflu prophylaxis reduced postexposure flu transmission in children aged 1-12 years by 82%.23